Patchwork Patchwork

Sample DNA Weight Loss Report

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Explanation

We present this report to you when you purchase a report and consult.

  1. First, we go through the top items that we noticed when we analyzed your DNA. The top items are the highest-effect items we think would be relevant to you, and this is where we explain how your DNA says you work.
  2. Then, we review our recommendations for you based on these items and explain them in more detail.
  3. Finally, we review the reference details, including everything we look for when analyzing your DNA. This is where all the explanations exist for the highlighted items in the top items.

You will receive a copy of this report after we present it to you. During the presentation, we can answer any questions you have or explain anything that is unclear. This sample report is from a fake person based mostly on multiple people who work at Patchwork. Yours would be different based on your DNA.

Icon Legend

A+
Unique
Strength
G
Works
Well
N
Neutral
W
Not the
Best
B
Has Issues
B
Avoidance
Suggested

Top Items

Macronutrients

🥔
Starch
🍞
Wheat &
Gluten
🍭
Simple
Sugars
🧈
Saturated
Fat
🥑
MUFA
🥜
PUFA
🍗
Protein
🥛
Dairy

Diets

🥔
High
Starch
🍚
Carbo
🗿
Paleo
🥦
Vegetarian
🍯
Honey /
High Sugar
🍖
High
Protein
🥦
Vegan
🧈
Ketogenic
🥩
Carnivore

Micronutrients

MTHFR
Folate
Conversion
B1
Thiamin
PEMT
Choline &
Betaine
☀️
Vitamin D
Cu
Copper

Toxins

MTHFR & PEMT
MTHFR
Detox
Fl
Fluoride
BPA
Bisphenol A
Pht
Phthalates

Inflammation & Intolerances

🤧
Inflammation
🧀
Histamine &
Tyramine

Hormones & Mental Health

♂
Testosterone
👤
Depression
🌅
Circadian
Rhythm

Recommendations

🥔 Histamine Avoiding Potato Diet

Whole Food Starches

Your genes suggest that a high-starch diet, avoiding grains and wheat, works best with your energy system. Foods high in histamine, tyramine and saturated fat will cause inflammation and block weight loss.

More Info

Secondary Option

🫐 Casual Histamine Avoidance Diet

Avoiding Inflammation

If the other diet is too hard-core for you. In that case, you can try a casual histamine and inflammation avoidance diet, favoring foods low in histamine, tyramine and saturated fat with starch as your primary fuel source when it's easy by default. We estimate about 1 or 2 lbs of fat loss per month on this diet.

More Info

Daily Supplement Plan

💊
Methylfolate
400mcg
💊
Choline
1100mg
💊
TMG / Betaine
750mg
💪
Creatine
+5g
B1
Benfotiamine
300mg
Cu
Copper
2.5mg
☀️
Sunlight
5000 IU
More Info

High Priority

  • Methylation Support
    • Choline: 1100 mg/day through food and supplements. Or about 8 large egg yolks a day. You have multiple choline genetics that suggests direct choline supplementation & ingestion is beneficial for you. Creating choline is a significant methylation load on your body, so supplementing it will help.
      • Alpha-GPC: 600 mg/day. Alpha-GPC is a choline metabolite generated by the body that crosses the blood-brain barrier. Since you have brain energy issues, partly supplementing this form will help.
    • Methylfolate: Methylated B12, B6 & Methylfolate combined supplement. These need to be in specific forms to be effective, which this supplement provides in one easy pill.
    • TMG / Betaine: 750 mg/day. You have specific genetics that suggest worse choline to betaine conversion; this supplement helps with that.
    • Creatine: +5g / day. Synthesizing creatine creates 40% of the methylation load on your body. By eating it directly, you remove this demand from your body.
  • Vitamin D & Sunlight: 5000 IU / day generated from light exposure from sunlight or a Vitamin D lamp. If neither is practical, then a vitamin D3 + K2 supplement and getting it from food sources would be an option. Sunlight or a Vitamin D lamp is ideal since it also helps with nitric oxide production and would help with your circadian rhythm issues.
  • Benfotiamine: 300mg/day. This will help with your extra Thiamin needs and will also help you metabolize your starch better. This form will stay in your system longer and have more convert into usable Thiamin.
  • Copper: 2.5 mg/day if you have a low copper diet. Will need to take zinc and copper on separate meals a few hours apart since they compete in digestion.
    • Zinc: 30 mg/day to balance your copper consumption. Supplementing one without the other can cause depletion issues.

Medium Priority

  • Magnesium: 400 mg/day
  • Selenium: 100mcg / day for thyroid support.
  • Vitamin A Retinol: 300mg/day can help your beta carotene conversion issue.

Reference Details

Macronutrient Rules

🥔

Carbohydrates

🥔
Starches
🥕
Vegetables
🌾
Wheat &
Gluten
🍭
Simple
Sugars
🍇
Fructose
More Info
  • Starches come out on top in your genetics as your energy source of choice. Specific genes suggest you do better with starch converting into usable energy than most people.
  • Since carbs are your star energy source, simple sugars are not as bad as they would be for most people, but you have some genes that suggest some glucose regulation issues, so you will probably find them not working as well for you compared to starch. For your desserts, pure sugar desserts might be better than typical mixed fat and sugar dairy desserts.
  • Vegetables: We have not noticed specific issues with vegetables in your genetics.
  • You have some genes that suggest issues with wheat & gluten, so we suggest avoiding that kind of starch specifically. You might also want to be tested for celiac disease or non-celiac gluten sensitivity.
  • Fructose: You have some genes that suggest specific issues with fructose. You might notice high amounts of fructose block your weight loss, even if it comes from whole fruits.
🧈

Fat

🧈
Saturated
Fat
⚡️
Low Energy
Conversion
🐟
Seafood
Omega 3
🌱
Plant
Omega 3
🫒
Monoun-
saturated
🧈
Keto Diet
🥜
PUFA
More Info
  • Saturated Fat: You have several genes that suggest high amounts of inflammation with high enough saturated fat intake. This inflammation can block fat loss and make you feel low energy. On the bright side, by having a low saturated fat diet, you will get even more benefits from avoiding saturated fat than most people.
  • Low Energy Conversion: You have specific genes that suggest worse energy conversion from fat than most people. As a result, fat isn't your superstar fuel source like carbs is for you.
  • Keto Diet: You have specific genes that suggest worse energy conversion from fat than most people. If you go under a keto diet, you will probably feel low energy even if you lose weight with it, and it will be harder for you than most.
  • Monounsaturated Fat (MUFA): There are no issues here.
  • Plant Omega 3 Fats: You don't convert plant omega 3 oils as well, so focus on seafood omega 3 oils from actual fish.
  • Palmitic Acid vs Stearic Acid: No data in your genetics file
  • PUFA (Linoleic Acid / Omega 6 Fats / Polyunsaturated Fat): You don't have any specific PUFA genetics. The amount of PUFAs that people eat in their modern diet is also far higher than it historically has been and has been linked to increased inflammation, so reducing PUFAs is usually a good idea for most since it's easy to eat too much PUFA.
🍖

Protein

🐟
Fish
🥚
Eggs
🥛
Dairy
🍗
Chicken
🥓
Pork
🥩
Beef
🧀
Histamine
More Info
  • Dairy probably causes you issues. You don't have the lactase persistence genes, so you will probably have issues with the digestion of the lactose in dairy in some form or another. The digestive distress that dairy can cause you, even with lactase enzymes, can help prevent fat loss. On top of this, the fat in dairy is high in saturated fat, and your genetics with saturated fat are not good either. This combo leads to using dairy as a main protein source, which is probably not the best idea. Whey protein isolate is okay, but usually, it's better to get protein from whole sources due to processed isolates having a higher risk of contamination. You can still have some dairy as a treat, but we don't advise it as a main protein source.
  • You have multiple histamine intolerance genes. This means foods high in histamine, which tends to be fermented or less fresh foods, will probably not agree well with you. You will benefit from eating the freshest foods possible and avoiding leftovers. Since as foods sit, they develop more histamine. Eating many frozen foods will be some of the freshest food you can eat.
  • Beef: Beef is okay but tends to be high in saturated fat. Lean cuts of beef will probably be better for you as a result.
  • Chicken & Pork: Chicken and pork are okay but high in PUFAs. Lean cuts of chicken or pork will be the better choice. If you can buy wild pork or chicken, they tend not to have a lot of PUFAs, but they also cost as much as purchasing beef and are hard to find.
  • Fish is probably your ideal protein source. Its high amount of omega-3 fats helps with inflammation and other issues, and it is low in omega-6 and saturated fats.
  • Eggs: Eggs are a good protein source for you since the yolks are rich in choline, which you have an elevated need for, and do not have a lot of saturated fats. Make sure to cook your egg whites fully, or the enzyme inside them might reduce your biotin levels significantly, which you have an elevated need for. Don't fret if you have a little bit of raw egg white if you've cooked most of them, but don't pick up a raw egg habit.
  • Protein comes with other nutrients: Many people don't have issues with protein digestion, so our protein suggestions are based on other nutrients that work well with you since it's rare for a complete protein source not to come with some fat. In most cases, people won't have issues with pure protein sources, but it can be challenging to get protein in that form unless it's processed. Only certain fish, such as Cod and egg whites, come in a pure protein form. Plant sources are often incomplete and can come with their issues.

Micronutrients & Diet

Micronutrient Details

MTHFR
Folate
Conversion
PEMT
Choline &
Betaine
🍳
Sulfur
Metabolism
☀️
Vitamin D
Fe
Iron
Bio
Biotin
B2
Riboflavin
B1
Thiamin
Zn
Zinc
Cu
Copper
Se
Selenium
💪
Creatine
🥕
Beta
Carotene
Mg
Magnesium
More Info
  • Folate Conversion: Like many people in the USA, you have about an 85% reduction in folate conversion and the issues that come from it. MTHFR and other related genes modulate how efficiently you convert nonbioavailable folate into other nutrients. If you have problems here, it can create a lot of other knock-on effects in many different systems of the body. To help support this entire metabolic system, we recommend a combination of supplements and doses to help address these issues for you.
  • Choline & Betaine: You have some choline and betaine enzyme genetics issues, so direct supplementation can help you here, too. This also interacts with your Folate Conversion genetics, so supplementing both is a significant improvement.
  • Sulfur Metabolism: Fortunately, you have no issues with your sulfur metabolism.
  • Vitamin D: You probably have Vitamin D issues, which interact with iron metabolism and your production of Nitric Oxide. Targeting improved vitamin D can probably help you in many ways. This also probably interacts with seasonal affective disorder if you have it, and it interacts with your circadian rhythm issues. We believe a Vitamin D lamp or regular sun exposure will help with the problems represented here.
  • Biotin: You have some biotin genetics that suggests you would benefit from more biotin, so supplementing it could help. Biotin supplementation invalidates a lot of blood tests, so make sure to ask your doctor how long you should stop taking biotin before you get your blood work drawn to get a proper reading.
  • Riboflavin: You don't have any genetics we analyze that suggest you have issues with riboflavin.
  • Thiamin: You have some Thiamin genetics that suggests you would benefit from more Thiamin, so supplementing it could help. With your key macronutrient being carbohydrates, Thiamin supplementation will also help you extract more energy from your carbs.
  • Zinc: Zinc might decrease blood glucose if you are insufficient. Could be helpful to supplement.
  • Selenium: You have some decreased selenium in your genetics, but it's not to a significant degree.
  • Creatine: Nothing stands out here.
  • Vitamin A: Decreased beta carotene conversion means you might need more retinol vitamin A in your diet.
  • Magnesium: You would benefit from more magnesium in your diet due to your direct genetics and the interaction of other things mentioned in this report.
  • Copper: You have some copper genetics that suggests you would benefit from more copper in your diet.

Diet Miscellaneous

😤
Hangry
🍬
Sweet Tooth
GLP
GLP-1 /
Ozempic
More Info
  • Fasting: You have the gene that would increase your chances of being hangry when you don't eat. Fasting is probably harder for you.
  • Sweet Tooth: You have the gene that would increase your preference for sweet things but also make their effect on your blood sugar better regulated.
  • Natural GLP-1 / Ozempic Effectiveness: Your genetics suggest GLP-1 medications might not be as effective for you.

Toxins & Inflammation

Toxins

MTHFR & PEMT
MTHFR
Detox
🍺
Alcohol &
Aldehydes
Hg
Mercury
Fl
Fluoride
Ar
Arsenic
BPA
Bisphenol A
Ox
Oxalates
Pb
Lead
Pht
Phthalates
More Info
  • MTHFR Detox: MTHFR and other Methylation genes are very central in supporting detox processes. This makes detox worse for you than usual. Fortunately, you can make this much better with supplementation.
  • Alcohol & Aldehydes: You convert alcohol into aldehydes quicker, which might mean alcohol hits you harder.
  • Mercury: Your genes don't stand out as having increased issues beyond the norm with mercury. Mercury is still bad for everyone.
  • Fluoride: Reduction in T4 thyroid hormone in a study on children with your genes.
  • Oxalates: Nothing stands out from the norm.
  • Lead: You might have more inflammation than average when exposed to lead.
  • Arsenic: Nothing stands out from the norm. Arsenic is still bad for everyone.
  • Bisphenol A (BPA): Multiple genes with increased risk of liver dysfunction with BPA exposure.
  • Phthalates: Slower elimination of phthalates.

Inflammation & Intolerances

🤧
Inflammation
🥜
Food
Allergies
🍄
Mushrooms
🪼
Emulsifiers
💩
IBD
🧀
Histamine &
Tyramine
More Info
  • Chronic Inflammation: Increased risk of chronic inflammation and stronger inflammatory responses.
  • Food Allergies: Increased risk of wheat allergy and gluten intolerance.
  • Mushrooms: Might be intolerant to ergothioneine in mushrooms with IBD (heterozygous).
  • Emulsifiers: Your genetics show an inflammation and emulsifier issue. Reducing and avoiding emulsifiers might help your probable stomach and gut issues. Lecithin and egg yolks will still be okay in your diet and are a source of choline.
  • IBD: Increased risk of IBD.
  • Histamine & Tyramine: You have multiple genes suggesting issues with histamine & tyramine breakdown and processing, often linked to inflammation. Reducing histamine and tyramine foods will probably help you here.

Hormones & Mental Health

Hormones

♀
Estrogen
♂
Testosterone
🔥
Thyroid
🫂
Oxytocin
More Info
  • Estrogen: You have some genes that lead to a decrease in estrogen metabolism. Metabolism means how fast your body processes or eliminates the hormone as it is produced. Men produce estrogen, but at much smaller levels, no estrogen is bad for men. Women are similar to testosterone. It might not have much impact since you are male, but you may benefit from getting it tested by a healthcare professional.
  • Testosterone: Higher SHBG level association, which binds to testosterone & other hormones to make them inert. SHBG binds to testosterone more than others. You also have different genes suggesting reduced testosterone levels and lower androgen receptor sensitivity. A testosterone + SHBG panel might be helpful. Reduced testosterone levels are associated with increased weight gain and depression.
  • Thyroid: You have a slightly increased risk of hypothyroidism. A thyroid panel might be helpful.
  • Oxytocin: Nothing stands out from the norm.

Mental Health & Neurotransmitters

🌅
Circadian
Rhythm
👤
Depression
D
Dopamine
☕️
Caffeine
C
COMT
More Info
  • Circadian Rhythm: You have multiple genes that suggest issues with circadian rhythm management, which indicates a higher sensitivity to light in your circadian rhythm cycle. Managing your blue, violet (near UV), green and red light stimulus could help you with sleep management. During daytime hours, you want to make sure you get enough 5600K light, and during the nighttime, strive to avoid blue light sources such as cheap LED lights and turn on color filters on all of your screens to block out most blue & green light, focusing on yellow, orange and red light sources. 2700K or even 2000K light bulbs would be ideal, but buying light bulbs with a kelvin color rating below 2700K is difficult. Daytime blue light is also essential in maintaining your circadian rhythm. A morning wake-up walk will also probably help you sleep later at night. Your genes also predict you are probably a night owl. Good sleep and circadian rhythm management help significantly with fat loss.
  • Depression: You have increased inflammation linked to depression risk. Reducing your inflammation via histamine avoidance, increased omega-3 fats, detoxing heavy metals and avoiding sources of inflammation such as mold might help here and in your overall health & fat loss goals.
  • Caffeine: Your genes suggest you digest caffeine quickly and don't have an anxiety response. You might be the kind of person who can drink a coffee 2 hours before bed and fall asleep fine.
  • Dopamine: You might do better with rule-based learning. You might be somewhat more novelty-seeking.
  • COMT: Intermediate-slow COMT activity. COMT is an enzyme that breaks down many neurotransmitters, including dopamine and vitamins such as folate. A high or "fast" COMT is associated with a higher need for folate and dopamine, while a low or "slow" one has a reduced need. You are in the middle, like most people in the USA.

Medical Disclaimer

This DNA analysis report is for informational purposes only and is not intended to be used as medical advice. The genetic information provided is based on current research but should not be used to diagnose, treat, cure, or prevent any disease or health condition.

  • Always consult with qualified healthcare providers regarding your specific health situation.
  • Genetic information is just one of many factors that influence health outcomes.
  • Research in genetics is ongoing, and interpretations may change as new evidence emerges.
  • Lifestyle, environment, and other factors play crucial roles in health outcomes.
  • Genetics strongly interacts with environment, lifestyle, and other factors. Genetics are not certainties, but probabilities.

By using this report, you acknowledge that you understand these limitations and will discuss any health-related decisions with qualified healthcare professionals.